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Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 101-111 doi: 10.1007/s11684-019-0698-4
关键词: mismatch repair protein deficiency (MMR-D) microsatellite instability (MSI) short tandem repeats (STR) gastrointestinal tumor hypermutability
Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma
Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He
《医学前沿(英文)》 2019年 第13卷 第6期 页码 730-740 doi: 10.1007/s11684-019-0687-7
关键词: upper tract urothelial carcinoma GATA binding protein 3 mismatch repair microsatellite instability prognosis
Novel polymorphic EST-based microsatellite marker isolation and characterization from
Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG
《农业科学与工程前沿(英文)》 2015年 第2卷 第1期 页码 60-65 doi: 10.15302/J-FASE-2015048
Combustion instability detection using the wavelet detail of pressure fluctuations
JI Junjie, LUO Yonghao
《能源前沿(英文)》 2008年 第2卷 第1期 页码 116-120 doi: 10.1007/s11708-008-0019-0
关键词: comparison wavelet approximation pressure transducer general pressure consistent
高伟健,李伟
《中国工程科学》 2023年 第25卷 第3期 页码 109-121 doi: 10.15302/J-SSCAE-2023.03.010
海底不稳定性及次生海底地质灾害广泛存在于海洋之中,对海岸港口设施、海洋钻井平台、海底管道光缆等海底基础建设颇具威胁。但目前对海底不稳定性的成因机制与主控因素仍知之甚少,为加深对海底不稳定性的认识,本文回顾了海底不稳定性研究进展,梳理了海底不稳定性及次生海底地质灾害的主要类别、全球分布情况和地球物理识别特征,归纳了目前海底不稳定性研究的定量分析方法,进一步分析了其成因机制、控制因素及工程地质灾害风险,探讨了海底陆坡失稳演化过程试验模拟技术的适用范畴与技术瓶颈。最后,从海底不稳定性的致灾机理研究、多源数据智能分析和海底失稳立体监测3 个维度提出了未来海底不稳定性研究的发展方向与对策建议,以期为海底不稳定性的模拟、预测和预警等工作提供指导性建议。
黄殿武,乔玲,汪时机
《中国工程科学》 2007年 第9卷 第4期 页码 50-54
采用弹性理论研究了圆柱形胶体在表面张力作用下的弹性失稳问题;利用能量泛函变分的方法导出 了发生弹性失稳的非经典边界条件,得到了失稳的判据方程。分析判据方程发现,弹性失稳与圆柱体的半径、 内禀尺度和失稳波长相关。
工程饱和介质中漩涡光的调制不稳定性 Review
D.G. Pires, N.M. Litchinitser
《工程(英文)》 2022年 第17卷 第10期 页码 31-43 doi: 10.1016/j.eng.2022.04.022
光束在水下环境、雾、云或生物组织等混浊介质中的传播在科学和技术中有着越来越重要的应用,包括生物成像、水下和自由空间通信技术。虽然这些应用在传统上依赖于常规的线性偏振高斯光束,但光具有许多未被发掘的自由度,如自旋角动量(SAM)和轨道角动量(OAM)。本文提出了具有“旋转”自由度的复杂光束在工程化非线性胶体介质中的非线性光-物质相互作用。利用变分法和摄动法,我们考虑了非圆柱光学涡旋、椭圆光学涡旋和高阶贝塞尔光束在时间上的积分(HOBBIT),来预测这些光束演化的动力学行为和稳定性。这些结果可应用于许多强散射环境下涉及光透射的情况。
关键词: Optical vortex Orbital angular momentum Modulation instability Turbid media
Underlying mechanism of the hydrothermal instability of Cu
Nadeen Al-Janabi,Abdullatif Alfutimie,Flor R. Siperstein,Xiaolei Fan
《化学科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 103-107 doi: 10.1007/s11705-015-1552-0
关键词: hydrothermal stability metal-organic framework (MOF) open metal sites (OMSs) dynamic water vapour adsorption
Mechanisms and impacts of chromosomal translocations in cancers
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 263-274 doi: 10.1007/s11684-012-0215-5
Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia. In the past few decades, tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations. This review focuses on the basic mechanisms underlying the generation of chromosomal translocations. In particular, the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.
关键词: DNA double strand breaks chromosomal translocations genomic instability spatial proximity carcinogenesis
p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 320-329 doi: 10.1007/s11684-016-0463-x
Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients. p-Cresyl sulfate (PCS) is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE−/− mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group (n = 20) and PCS-treated group (n = 20). Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells (VSMCs) were treated with phosphate buffer solution or 500 µmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.
关键词: p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell
Aerodynamic stability evolution tendency of suspension bridges with spans from 1000 to 5000 m
《结构与土木工程前沿(英文)》 doi: 10.1007/s11709-023-0980-z
关键词: suspension bridge super long-span finite element model aerodynamic instability aerodynamic configuration
Chunji YAN, Maozhao XIE,
《能源前沿(英文)》 2010年 第4卷 第2期 页码 198-204 doi: 10.1007/s11708-009-0054-5
关键词: liquid jet dominant wave number compressibility instability
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 332-337 doi: 10.1007/s11684-012-0212-8
Bedside limited echocardiography, or focused cardiac ultrasound, continues to gain popularity in many emergency rooms, intensive care units, and operating rooms as a rapid method of assessing unstable patients. Effective monitoring of cardiovascular function in conditions like cardiac arrest or near-arrest is the crucial step to guide successful resuscitative efforts. Transesophageal echocardiography (TEE) has emerged as one of the preferred cardiac diagnostic and monitoring modalities in the intraoperative setting due to the fact that it is less invasive than many other monitors, is immediately accessible, and allows for continuous real-time monitoring of cardiac function. However, the minimum training requirements needed for the anesthesia provider to obtain the competency, knowledge, and skills for basic certification in perioperative TEE far exceed those developed for other medical specialties. We believe there is an urgent need to develop (1) practical guidelines for emergent perioperative TEE use for anesthesiologists and (2) a requisite educational curriculum to teach the basic skills necessary to aid in the diagnosis and treatment of cardiac arrest or near-arrest scenarios. The measures elucidated in this report summarize the efforts of the Department of Anesthesiology at the University of Florida in establishing the necessary steps to make this process not only practical, but accessible to all trainees. We hope that these collective efforts will provide more trainees the confidence in utilizing TEE to aid in establishing a diagnosis in critical situations.
关键词: transesophageal echocardiography curriculum competency training hemodynamic instability
Generation and repair of AID-initiated DNA lesions in B lymphocytes
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 201-216 doi: 10.1007/s11684-014-0324-4
Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.
关键词: class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability
Nazim Abdul NARIMAN
《结构与土木工程前沿(英文)》 2017年 第11卷 第2期 页码 131-142 doi: 10.1007/s11709-016-0376-4
关键词: aeroelastic instability structural damping flutter wind speed bending stiffness torsional stiffness
标题 作者 时间 类型 操作
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
期刊论文
Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma
Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He
期刊论文
Novel polymorphic EST-based microsatellite marker isolation and characterization from
Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG
期刊论文
Combustion instability detection using the wavelet detail of pressure fluctuations
JI Junjie, LUO Yonghao
期刊论文
Underlying mechanism of the hydrothermal instability of Cu
Nadeen Al-Janabi,Abdullatif Alfutimie,Flor R. Siperstein,Xiaolei Fan
期刊论文
p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by
null
期刊论文
Stability of an annular viscous liquid jet in compressible gases with different properties inside and outside of the jet
Chunji YAN, Maozhao XIE,
期刊论文
Emergent limited perioperative transesophageal echocardiography: should new guidelines exist for limited echocardiography training for anesthesiologists?
null
期刊论文